Cid episode 12471/3/2023 The aOR of neurosyphilis at the index episode was also significantly lower in individuals with previous syphilis (0.43 95% CI. pallidum DNA in blood or rRNA in CSF at the index episode were significantly lower in those with previous syphilis (0.13 95% CI. This difference was not explained by frequency of serological tests. The proportion of individuals whose index episode was asymptomatic significantly increased with increased number of syphilis episodes (P <. Odds ratios (ORs) with 95% confidence intervals (CIs) were determined using logistic regression.ħ01 individuals had 1 (n = 478), 2 (n = 155), or ≥3 (n = 68) episodes of syphilis. Treponema pallidum DNA in blood and rRNA in CSF were detected using polymerase chain reaction (PCR) and reverse transcriptase PCR. The total number of syphilis episodes was determined by review of medical and public health records. Venipuncture and lumbar puncture were performed. For each participant, the index episode was defined as the most recent syphilis episode for which the study entry visit was performed within 30 days of the syphilis diagnosis date. Individuals enrolled in a study of cerebrospinal fluid (CSF) abnormalities in syphilis were allowed to enroll in the study again with subsequent syphilis. Individuals with previous syphilis may be more likely to be asymptomatic when they are reinfected with Treponema pallidum.
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